Pharmacy Benefit Management (PBM) in the United States plays a crucial role in managing prescription drug benefits for health insurance plans and self-insured employers. PBMs negotiate with drug manufacturers to secure rebates and discounts on medications, ensuring cost-effective options for clients. They also work with pharmacies to establish networks, process claims, and implement clinical programs designed to improve medication adherence and overall health outcomes. Additionally, PBMs analyze data to identify trends, control costs, and provide insights into prescribing patterns. With their industry expertise and technological capabilities, PBMs help streamline the complex pharmaceutical supply chain while ensuring access to affordable medications for millions of Americans. In recent years, PBMs have faced increased scrutiny over pricing practices and their influence on drug distribution channels, leading to ongoing debates about transparency and accountability within the healthcare system.