When choosing between Django and Flask for Python web development, both frameworks offer unique advantages. Django is a high-level framework that promotes rapid development with its built-in features, such as an admin panel and ORM, making it ideal for complex applications. It emphasizes convention over configuration, which can speed up the development process. Flask, on the other hand, is a lightweight micro-framework that provides greater flexibility and control. It’s perfect for smaller projects or when you need to customize your application extensively. Ultimately, the choice between Django and Flask depends on your project requirements and desired level of control.