This article explores how multi-methodology research can help decision-makers reduce uncertainty around ambitious, high-risk “moonshot” investments, especially during volatile economic conditions. It argues that relying on a single research method often leaves gaps in understanding, while a structured combination of qualitative and quantitative approaches provides a more complete and balanced evidence base. By using complementary methods—such as in-depth interviews, surveys, and secondary research—organizations can uncover motivations, validate trends, and triangulate insights to improve investment decisions. The piece highlights how this blended research strategy strengthens confidence, reveals hidden risks, and supports better judgments across an investment’s lifecycle.