The global oligonucleotide synthesis reagents market size was estimated at USD 723.3 million in 2025 and is projected to reach USD 1751.3 million by 2033, growing at a CAGR of 11.9% from 2026 to 2033. The growth is driven by increasing demand for oligonucleotide-based therapeutics, expanding applications in diagnostics and genomics, and advancements in DNA/RNA synthesis technologies.