Is anyone feel depressed after wearing Tulsi mala?

There is no scientific evidence that wearing a Tulsi mala causes depression. However, one should follow the Tulsi mala pehenne ke niyam (rules for wearing the Tulsi mala) to avoid any discomfort or negative feelings. According to tradition, the mala should be worn with respect and care, ideally during meditation or prayer. If it's not properly cleansed, or if worn with impure thoughts or intentions, some people may not feel well or be comfortable.