Pharmacological and toxicological screening methods are essential in the development of new drugs, ensuring they are both effective and safe for human use. These methods are used to assess the therapeutic potential, as well as the possible harmful effects of substances, typically through in vitro (cell-based) and in vivo (animal-based) testing, and sometimes through computational techniques. By identifying promising compounds and rejecting harmful ones early in the development process, these screenings help mitigate risks to human health and improve the likelihood of successful clinical trials.